Flower color in snapdragons

Mendel’s results in crossing peas, black vs brown fur color, and eumelanin production vs pheomelanin production all demonstrate traits are inherited as dominant and recessive. This contradicts the historical view that offspring always exhibited a blend of their parents’ traits. However, sometimes heterozygote phenotype is intermediate between the two parents. For example, in the snapdragon, Antirrhinum majus (Figure 20), a cross between a homozygous parent with white flowers (C^WC^W) and a homozygous parent with red flowers (C^RC^R) will produce offspring with pink flowers (C^RC^W) (Figure 21).

Note that different genotypic abbreviations are used to distinguish these patterns from simple dominance and recessiveness. The abbreviation C^W  can be read as “at the flower color gene (C), the white allele is present.”

This pattern of inheritance is described as incomplete dominance, meaning that neither of the alleles is completely dominant over the other: both alleles can be seen at the same time. The allele for red flowers is incompletely dominant over the allele for white flowers. Red + white = pink. The results of a cross where the alleles are incompletely dominant can still be predicted, just as with complete dominant and recessive crosses. Figure 22 shows the results from a cross between two heterozygous individuals: C^RC^W x C^RC^W . The expected offspring would have the genotypic ratio 1 C^RC^R:2 C^RC^W:1 C^WC^W, and the phenotypic ratio would be 1:2:1 for red:pink:white. The basis for the intermediate color in the heterozygote is simply that the pigment produced by the red allele (anthocyanin) is diluted in the heterozygote and therefore appears pink because of the white background of the flower petals.

Straight, curly, and wavy hair in dogs

Another example of incomplete dominance is the inheritance of straight, wavy, and curly hair in dogs. The KRT71 gene is used to synthesize the keratin 71 protein. Genes in the KRT family provide instructions for making proteins called keratins. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Epithelial cells make up tissues such as the hair, skin, and nails. These cells also line the internal organs and are an important part of many glands.

Keratins are best known for providing strength and resilience to cells that form the hair, skin, and nails. These proteins allow tissues to resist damage from friction and minor trauma, such as rubbing and scratching. Keratins are also involved in several other critical cell functions, including cell movement (migration), regulation of cell size, cell growth and division (proliferation), wound healing, and transport of materials within cells. Different combinations of keratin proteins are found in different tissues.

The mutation which causes curly hair in dogs, such as the labradoodle seen in Figure 23, is in exon 2 of the gene and is predicted to substantially disrupt the structure of the keratin 71 protein (Cadieu, 2009). This change in protein shape prevents the keratin proteins from interacting together correctly within the hair, altering the structure of the hair and resulting in a curly coat (Runkel, 2006).

When a dog has two curly alleles (K^CK^C), it has a very curly coat, such as on the poodle in Figure 24. A dog with two straight alleles (K⁺K⁺) has a straight coat. Dogs that are heterozygous (K⁺K^C) have an intermediate or wavy coat like the labradoodle in Figure 23.

References

Unless otherwise noted, images on this page are licensed under CC-BY 4.0 by OpenStax.

Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. 2009. Coat variation in the domestic dog is governed by variants in three genes. Science. 326(5949):150-3.

Runkel F, Klaften M, Koch K, Böhnert V, Büssow H, Fuchs H, Franz T, Hrabé de Angelis M. 2006. Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13. Mamm Genome. 17(12):1172-82.

OpenStax, Biology. OpenStax CNX. May 27, 2016 http://cnx.org/contents/s8Hh0oOc@9.10:zLLYW2hj@5/Extensions-of-the-Laws-of-Inhe

“Blood Group Antigens” by Genetics Home Reference: Your Guide to Understanding Genetic Conditions, National Institutes of Health: U.S> National Library of Medicine is in the Public Domain

“Keratins” by Genetics Home Reference: Your Guide to Understanding Genetic Conditions, National Institutes of Health: U.S> National Library of Medicine is in the Public Domain