Nitroglycerin (NTG)
Class: Nitrate
Mechanism of Action: Causes vasodilation that reduces preload/afterload thereby reducing cardiac workload and myocardial oxygen demand. Dilates coronary arteries, resulting in improved perfusion to ischemic myocardium. Relief of ischemia is thought to alleviate chest pain.
Onset: Rapid
Indications: Suspected ischemic chest pain, ACS
Contraindications: Hypotension (generally systolic < 100mmHg)
Recent use of erectile dysfunction medications [e.g. Viagra (sildenafil citrate) and Lavitra (vardenafil) within last 24 hr, Cialis (tadalafil) within last 48 hr]
Precautions: Check vitals before each administration, NTG induced hypotension responds well to supine positioning.
Side Effects: Hypotension, headache, dizziness, dry mouth
Dosage: 1 tablet / metered dose spray,(0.4 mg) given sublingually every 5 minutes. Note* some protocols have maximum repeat dosages.
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Nitroglycerin |
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4 |
5 IM (instructor) |
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Initials |
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